27th Young Statisticians Meeting

Session

Session 5

1 Oct 2023, 10:00

School of Applied Mathematics and Informatics, University of Osijek, Croatia

Conveners

Session 5: Statistical Methodology and Medical Statistics

• Paola Berchialla

1. Sample size calculation algorithm in two-stage three-arm sequential non-inferiority clinical trials: A simulation study (10)

Maria Vittoria Chiaruttini (Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy)

01/10/2023, 10:00

Non-inferiority studies play a crucial role in evaluating new treatments that offer potential benefits, such as reduced side effects, lower costs, or faster treatment times, compared to existing effective treatments. To determine whether a new treatment is not significantly worse than the reference treatment by more than a specified margin, non-inferiority studies are designed. However, a...

2. Study of Risk Factors for Pulmonary Exacerbations in Patients with Cystic Fibrosis and the Effects of New CFTR Modulator Therapy on Chronic Bronchial Infection and Pulmonary Exacerbations in a Real-Life Study (12)

Piercesare Grimaldi (Department of Public Health and Pediatrics, University of Torino)

01/10/2023, 10:30

Pulmonary exacerbations in cystic fibrosis (CF) patients have significant impacts on morbidity, mortality, and quality of life. This study aims to identify risk factors for exacerbations, evaluate the effects of new CFTR modulator therapy, and analyze factors influencing patient response to the therapy. This retrospective, single-center observational study involved CF patients treated with...

5. Modelling antibody kinetics – When and how often to measure? (7)

Stefan Embacher (Medical University of Graz)

01/10/2023, 11:00

Infectious diseases play a substantial role in global public health concerns, and the evaluation of interventions aimed at reducing the burden of infection, such as vaccination, need rigorous studies to
assess their effectiveness and efficiency. Measuring antibodies is a possibility to quantify the impact of a vaccination, and the modelling of antibody kinetics, i.e. the change of antibody...